The present study was carried out to formulate mouth dissolving dissolving tablets (MDTs) of Cyproheptadine HCl for enhanced solubility and dissolution profile in comparison to the marketed formulation. In our study, MDTs were prepared by Sublimation method using camphor, thymol and menthol as subliming agent. For solubility enhancement of Cyproheptadine HCl, solid dispersion with Poloxamer 407 was prepared and used in formulation. All the prepared formulations were evaluated for general appearance, physical parameters, drug content and In vitro drug release studies. The properties of all the formulations were found to be within the standard limits. All the MDTs get dispersed within a minutes when tested for In vitro dispersion. The In vitro drug release of MDTs (F7) shows good release with 45.4±0.17 % in 5 minutes, which increased up to 98.3±0.35% in 30 minutes in comparison to Marketed tablet which shows only 14.7±0.36% in 5 min. and fails to release more than 34.5±0.75% within 30 minutes.
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